Crystal Reed made her debut in the 2010 Greg and Colin Strause-directed American science fiction disaster film ‘Skyline’ where she played the role of ‘Denise.’ While the film received a lukewarm response from critics, it managed to gross over $68.3 million on a budget of $10–20 million. That same year, she also made an appearance in the television series like ‘CSI: Crime Scene Investigation’ (2010), ‘CSI: NY’ (2010), ‘The Hard Times of RJ Berger’ (2010), and ‘Rizzoli & Isles’ (2010). In 2011, she starred as ‘Amy Johnson’ in the American romantic comedy film ‘Crazy, Stupid, Love’ directed by Glenn Ficarra and John Requa. The film received a positive response from critics and was a commercial success, grossing over $145 million on a $50 million budget. That same year, she also joined the cast of the American supernatural teen drama television series ‘Teen Wolf’ where she grabbed the role of ‘Allison Argent.’ She received 3 ‘Teen Choice Award’ nominations for her performance and remained a part of the series until 2014.
She starred as ‘Rebecca Ogin’ in the 2012 independent comedy film ‘Jewtopia’ directed by Bryan Fogel. The film received mostly negative reviews from critics. After starring in films like ‘Crush’ (2013) and ‘Too Late’ (2015), she became a part of the American superhero crime drama television series ‘Gotham’ in 2017. She played the role of ‘Sofia Falcone’ and remained a part of the show until 2018. She next portrayed ‘Elizabeth "Beth" Keller’ in the 2018 horror film ‘Ghostland’ directed by Pascal Laugier. The film received a mixed response from critics and scored a 55% approval rating on Rotten Tomatoes. In 2019, she starred as ‘Abigail "Abby" Arcane’ in the American superhero horror television series ‘Swamp Thing.’ The series was canceled after one season. She was last seen in the 2022 film ‘Teen Wolf: The Movie’ where she reprised her role as ‘Allison Argent.’