Alisha Boe made her debut in the 2008 American anthology horror film ‘Amusement’ directed by John Simpson. The film received mostly negative reviews from critics. In 2012, she starred as ‘Tara’ in the American found footage supernatural horror film ‘Paranormal Activity 4’ directed by Henry Joost and Ariel Schulman. While the film received a lukewarm response from critics, it emerged as a massive critical success, grossing over $142.8 million on a budget of $5 million. That same year, she also appeared in the Episode: "Everything Is Not Okay" of the American family comedy-drama television series ‘Parenthood.’ She next appeared in television series like ‘Trophy Wife’ (2013), ‘Modern Family’ (2014), ‘Extant’ (2014), and ‘Days of Our Lives’ (2014-2015). In 2015, she became a part of the American crime drama television series ‘Ray Donovan’ created by Ann Biderman. She played the role of ‘Janet’ and remained a part of the series until 2016. Boe also portrayed Gwen in the American supernatural teen drama television series ‘Teen Wolf’ in 2016. In 2017, she joined the main cast of the American teen drama television series ‘13 Reasons Why’ where she grabbed the role of ‘Jessica Davis.’ The series spawned 4 seasons before going off-air in 2020. In 2017, she also appeared in the American black comedy horror-thriller film ‘68 Kill’ directed by Trent Haaga. The film was based on Bryan Smith’s novel of the same name.
In 2019, she starred as ‘Chloe’ in the American comedy film ‘Poms’ directed by Zara Hayes. The film received rather unfavorable reviews from critics and received a 36% approval rating on Rotten Tomatoes. That same year, she also appeared in the Karen Maine-directed ‘Yes, God, Yes.’ The film was lauded by critics and scored a 93% approval rating on Rotten Tomatoes. Boe was last seen in the 2022 American comedy-drama film ‘When You Finish Saving the World’ directed by Jesse Eisenberg. The film received mostly positive reviews from critics.