Tyler Posey made his debut in the 2000 American drama film ‘Men of Honor’ where he made an uncredited appearance as a boy. The film received mixed reviews from critics. In 2001, he joined the main cast of the American medical drama series ‘Doc’ where he played the role of Raul Garcia.’ The series ran for 5 seasons before going off-air in 2004. He starred as ‘Mauro’ in the 2002 American action thriller film ‘Collateral Damage’ directed by Andrew Davis. The film was largely panned by critics and scored a 19% approval score on Rotten Tomatoes. That same year, he played the role of ‘Ty Ventura’ in the American romantic comedy-drama film ‘Maid in Manhattan’ directed by Wayne Wang. The film opened to a mixed critical reception and grossed over $163.8 million on a budget of $65 million. He was next seen in films like ‘Inside Out’ (2005), ‘Veritas, Prince of Truth’ (2007), and ‘Legendary’ (2010). In 2011, he grabbed the role of ‘Scott McCall’ in the American supernatural teen drama television series ‘Teen Wolf’ developed by Jeff Davis. The series spawned 6 seasons and aired its final episode in 2017.
He continued to star in television series and shows such as ‘Workaholics’ (2013), ‘The Exes’ (2014), ‘Wolf Watch’ (2014-2015), ‘Ridiculousness’ (2015), ‘Lip Sync Battle’ (2016), ‘Elena of Avalor’ (2016-2018, 2020), ‘Hell's Kitchen’ (2017), ‘Jane the Virgin’ (2017), ‘Marvel Rising: Secret Warriors’ (2018), ‘Sideswiped’ (2018), ‘Marvel Rising: Battle of the Bands’ (2019), Marvel Rising: Chasing Ghosts’ (2019), ‘Marvel Rising: Heart of Iron’ (2019), ‘Now Apocalypse’ (2019), ‘Scream: Resurrection’ (2019), and ‘Fast & Furious Spy Racers’ (2019-2021). He last appeared in the Episode: "Strong Beef & Flying Teeth!" of the American game show ‘Nickelodeon's Unfiltered’ in 2021.