Q'orianka Kilcher made her acting debut in the 2000 American Christmas fantasy comedy film ‘How the Grinch Stole Christmas’ directed by Ron Howard. Even though the film opened to a mixed reception, it still managed to earn over $345.1 million on a budget of $123 million. In 2005, she portrayed ‘Pocahontas’ in the Terrence Malick-directed historical romantic drama film ‘The New World.’ While the film received somewhat of a positive response from critics, it failed to perform at the box office. However, it later came to be considered one of the best films of the decade. Kilcher also won the ‘NBR Award,’ ‘ALMA Award,’ and the ‘Online Film Critics Society Award’ for her performance in the film. She was next seen in films like ‘The Linguists’ (2007), ‘The People Speak’ (2009), ‘Princess Kaiulani’ (2009), ‘Shouting Secrets’ (2011), ‘The Power of Few’ (2013), ‘Running Deer’ (2013), ‘Ben & Ara’ (2015), and ‘Te Ata’ (2016). In 2017, she appeared in the American Western film ‘Hostiles’ directed by Scott Cooper. The film received mostly positive reviews from critics and holds a 71% approval rating on Rotten Tomatoes. That same year, she was also seen in the American horror film ‘The Vault’ directed by Dan Bush. The film received a lukewarm response from critics. In 2019, she played the role of ‘Inca Princess Kawillaka’ in the James Bobin-directed American adventure comedy film, ‘Dora and the Lost City of Gold.’ The film was well-received by critics and grossed over $119.7 million on a budget of $49 million. The following year, she starred as ‘Mayor Tooma’ in the American science fiction Lovecraftian horror film ‘Color Out of Space’ directed by Richard Stanley. The film received a positive response from critics. She was last seen in the 2022 American comedy-drama road film ‘Dog’ directed by Channing Tatum and Reid Carolin. The film was a critical and commercial success.