Anthony Anderson was first seen in the Episode: "Nanna Don't Play" of the American sitcom ‘In the House’ in 1995. The following year, he joined the cast of the American teen sitcom ‘Hang Time’ as ‘Theodore "Teddy" Brodis, Jr.’ He starred in 39 episodes and parted ways from the show in 1998. He made his big-screen debut in the 1999 American comedy-drama film ‘Liberty Heights’ directed by Barry Levinson. The film received a positive response from critics and holds an 85% approval rating on Rotten Tomatoes. In 2000, he starred as ‘Maurice’ in the American action film ‘Romeo Must Die’ directed by Andrzej Bartkowiak. While the film opened to a mixed reception, it was a box office success and grossed over $91 million on a $25 million budget. That same year, he also played the role of ‘Nolan’ in the American crime comedy film ‘Big Momma's House’ directed by Raja Gosnell. The film received negative reviews from critics but turned out to be a box office success. He next starred in films like ‘See Spot Run’ (2001), ‘Exit Wounds’ (2001), ‘Kingdom Come’ (2001), ‘Barbershop’ (2002), ‘Kangaroo Jack’ (2003), ‘Malibu's Most Wanted’ (2003), ‘Harold & Kumar Go to White Castle’ (2004), ‘King's Ransom’ (2005), ‘Hoodwinked!’ (2005), ‘Scary Movie 4’ (2006), ‘The Departed’ (2006), and ‘Transformers’ (2007).
In 2008, he grabbed the role of ‘Detective Kevin Bernard’ in the American police procedural and legal drama television series ‘Law & Order’ created by ‘Dick Wolf.’ He remained a part of the show until it went off-air in 2010. However, he made a special appearance on the show after its revival in 2022. He continued to appear in television series and shows such as ‘Samantha Who’ (2008), ‘Shameless’ (2011), ‘Psych’ (2012), ‘Guys with Kids’ (2012-2013), and ‘Hollywood Game Night’ (2013-2014). In 2014, he became a part of the main cast of the American sitcom television series ‘Black-ish’ where he starred as ‘Andre "Dre" Johnson.’ The show ran for 8 seasons and aired its final episode in 2022. He next appeared in television shows like ‘Carnival Cravings with Anthony Anderson’ (2015), ‘To Tell the Truth’ (2016-present), ‘The Gong Show’ (2017), ‘Drop the Mic’ (2017), ‘Grown-ish’ (2018), ‘Mixed-ish’ (2019), and ‘Extreme Makeover: Home Edition’ (2020). In 2020, he made an appearance on the American television game show ‘Who Wants to Be a Millionaire.’