Jennifer Aniston made her debut as an uncredited extra in the 1988 American comic science fiction ‘Mac and Me’ directed by Stewart Raffill. The film was a critical and commercial disaster but received cult status in subsequent years. In 1990, she joined the cast of the American sitcom television series ‘Molloy.’ She played the role of ‘Courtney Walker’ and appeared in 7 episodes of the series. That same year, she also appeared in the television film ‘Camp Cucamonga’ directed by Roger Duchowny. She next appeared in television series like ‘Ferris Bueller’ (1990-1991), ‘The Edge’ (1992-1993), ‘Quantum Leap’ (1992), ‘Burke's Law’ (1994), and ‘Muddling Through’ (1994). In 1994, she joined the main cast of the American television sitcom ‘Friends’ created by David Crane and Marta Kauffman. She played the role of ‘Rachel Green’ which earned her several awards including the 'Golden Globe Award' and 'Primetime Emmy Award.' The show ran for 10 seasons and aired its final episode in 2004. In 1997, she starred as 'Kate Mosley' in the American romantic comedy film 'Picture Perfect' directed by Glenn Gordon Caron. The film opened to mixed reviews and grossed over $44.3 million on a budget of $18 million. The following year, she was seen playing the role of 'Nina Borowski' in the Nicholas Hytner-directed American romantic comedy-drama film 'The Object of My Affection.' The film received mixed reviews from critics and was a moderate commercial success.
She continued to star in films like 'Office Space' (1999), 'The Iron Giant' (1999), 'Rock Star' (2001), 'The Good Girl' (2002), 'Bruce Almighty' (2003), 'Along Came Polly' (2004), 'Derailed' (2005), 'Friends with Money' (2006), 'Marley & Me' (2008), 'Love Happens' (2009), and 'The Bounty Hunter' (2010). In 2011, she starred as Dr. Julia Harris in the American black comedy film 'Horrible Bosses' directed by Seth Gordon. The film saw mixed to positive reviews upon release and did decent business at the box office. She played the role of Sarah "Rose" O'Reilly in the 2013 American crime comedy film 'We're the Millers' directed by Rawson M. Thurber. Even though the film opened to mixed reviews, it was a major commercial success. In 2014, she reprised her role as 'Dr. Julia Harris' in 'Horrible Bosses 2,' the sequel to the 2011 film 'Horrible Bosses.' The film received a mixed response from critics and grossed over $107.7 million on a $42–57 million budget. She continued to star in films 'Unity' (2015), 'Mother's Day' (2016), 'Storks' (2016), 'Office Christmas Party' (2016), 'The Yellow Birds' (2017), Dumplin' (2018), and 'Murder Mystery' (2019). She was last seen in the Episode: “Diff'rent Strokes and The Facts of Life" of the television special 'Live in Front of a Studio Audience' in 2021.