Cole started his acting career along with his twin brother, Dylan Sprouse, when he was eight months old. They shared roles in films, commercials and television shows. Some of his noteworthy performances as a child actor include ‘The Master of Disguise,’ ‘Big Daddy,’ and ‘Grace Under Fire.’ His first role in which he did not appear with his brother was in ‘Friends,’ a NBC’s television sitcom where he performed the role of Ben. In a MadTv sketch the twin brothers appeared in their first role as separate characters in the same production.
In 2005, he appeared in ‘The Suite Life of Zack and Cody’ as Cody Martin next to his brother. In 2008, the role was reprised by him in ‘The Suite Life on Deck.’ Cole is seen currently in ‘Riverdale,’ a CW’s teen drama series where he is playing the role of Jughead Jones.
Some of his other notable performances include ‘Diary of a Sex Addict,’ ‘The Kings of Appletown,’ ‘Just For Kicks,’ ‘I Saw Mommy Kissing Santa Claus,’ ‘The Astronaut’s Wife,’ amongst others. He is currently working on a film titled ‘Five Feet Apart.’