Wentworth Miller was first seen in the "Go Fish" episode of the supernatural drama television series ‘Buffy the Vampire Slayer,’ in 1998. The following year, he appeared in the teen drama television series ‘Time of Your Life.’ He played the role of ‘Nelson’ and starred in 3 episodes of the series. In 2000, he made his big-screen debut in the direct-to-video flick ‘Romeo and Juliet,’ directed by Colin Cox. In the 2003 drama film ‘The Human Stain,’ Miller played the role of a ‘Young Coleman Silk.’ The film received mixed reviews on release but failed to garner success at the box office. That same year, she also starred in the action-horror film ‘Underworld,’ directed by Len Wiseman. Even though the film was panned by critics, it went on to become a financial success.Â
In 2005, he joined the main cast of the serial drama television series ‘Prison Break.’ He played the role of ‘Michael Scofield’ in the series which earned him 4 ‘Teen Choice Award’ nominations. ‘Prison Break’ aired 4 seasons and concluded in May 2009. It was revived for the fifth season in 2017. Miller next acted in several series, including ‘Ghost Whisperer’ (2005), ‘Family Guy’ (2009), ‘Law & Order: Special Victims Unit’ (2009), ‘House’ (2011), and ‘Young Justice’ (2013). In 2014, he starred as ‘Leonard Snart / Captain Cold’ in the American superhero television drama series ‘The Flash.’ He remained a part of the show until 2019. In 2016, Miller reprised his role as ‘Leonard Snart / Captain Cold’ in the superhero television series ‘Legends of Tomorrow.’ He made an exit from the show in 2019, but appeared in a few episodes in 2021.
In 2019, he starred as ‘ADA Isaiah Holmes’ in the American crime drama television series ‘Law & Order: Special Victims Unit.’ He appeared in 2 episodes of the series.