Jessica Capshaw made her debut in the 1997 American drama film ‘The Locusts,’ directed by John Patrick Kelley. The film received mostly negative reviews from critics. The following year, she starred as ‘Marcia’ in the American drama film ‘Denial,’ directed by Adam Rifkin. The film received mixed reviews upon release. In the 1999 American romantic comedy film ‘The Love Letter,’ Capshaw was seen playing the role of ‘Helen MacFarquhar.’ The film was panned by critics and was a box office bomb. That same year, she also joined the main cast of the American sitcom ‘Old Man Out’ where she played the role of ‘Aunt Jordan.’The show ran for 19 episodes and went off-air in 2000. In 2001, she starred as ‘Dorothy Wheeler’ in the slasher film ‘Valentine,’ directed by Jamie Blanks. Even though the film received mostly negative reviews upon release, it managed to come out as a financial success, grossing over $36.7 million on a budget of $10 million.
In the 2002 American science fiction action film ‘Minority Report,’ Capshaw played the role of ‘Evanna.’ The film saw critical acclaim upon release and was a major box office success, grossing over $358.4 million on a budget of $102 million. That same year, she also became a part of the American legal drama television series ‘The Practice.’ She played the role of ‘Jamie Stringer’ and remained a part of the series until it went off-air in 2004. Capshaw went on to appear in television series and shows such as ‘How I Met Your Mother’ (2005), ‘Into the West’ (2005), ‘Bones’ (2006), and ‘The L Word’ (2007). In 2008, she joined the cast of the American medical drama television series ‘Grey's Anatomy’ created by Shonda Rhimes. She played the role of ‘Dr. Arizona Robbins’ and remained a part of the series until 2018.
In 2014, she appeared in the American computer-animated film ‘The Hero of Color City’ directed by Frank Gladstone. The film received mostly negative reviews from critics. She was last seen in the 2020 American romantic comedy film ‘Holidate’ directed by John Whitesell. The film was released on Netflix and received mixed reviews from critics. Capshaw is all set to appear in the upcoming American drama film ‘Dear Zoe,’ directed by Gren Wells.