Giuliana Rancic made her debut in the 2003 American comedy film ‘Malibu's Most Wanted’ where she played the role of a massage therapist. The film received a lukewarm response from critics. The following year, she joined the American sitcom ‘One on One’ as ‘Reporter Tammy Towne.’ In 2005, she became a part of the entertainment news operation ‘E! News’ as a host. She remained a part of the news show until 2015. She later made a brief return to ‘E! News’ in 2018 and continued on the show until 2019. In 2007, Rancic made a cameo appearance in the American superhero film ‘Fantastic Four: Rise of the Silver Surfer’ directed by Tim Story. Despite receiving mixed to negative reviews from critics, the film came out as a financial success. In 2010, she was cast in the American reality television series ‘Giuliana and Bill,’ alongside her husband Bill Rancic. The show aired 79 episodes and went off-air in 2014. In 2010, Rancic also joined the cast of the American television series, ‘Fashion Police,’ as a co-host. The series aired its final episode in 2017.
She next appeared in television series and shows such as ‘After Lately’ (2011), ‘Chelsea Lately’ (2011), ‘E! True Hollywood Story’ (2012), and ‘Ready for Love’ (2013). Rancic also co-hosted the Miss USA pageant in 2011, 2012, 2013, and 2014. She was last seen in the 2020 American romantic comedy film ‘The Stand In’ directed by Jamie Babbit. The film saw mostly negative reviews upon release and scored an approval rating of 30% on Rotten Tomatoes.