Devon Bostick first appeared in the crime television series ‘Exhibit A: Secrets of Forensic Science’ in 1998. In 2002, he joined the cast of the Canadian science fiction series ‘Odyssey 5.’ He remained a part of the series until 2003. Bostick made his big-screen debut in the 2004 Canadian-American horror drama-thriller film ‘Godsend,’ directed by Nick Hamm. The film received negative reviews from critics. The following year, he starred as ‘Brian’ in the post-apocalyptic horror film ‘Land of the Dead,’ directed by George A. Romero. The film opened to positive reception and was a box office success, grossing over $46.8 million on a budget of $15–19 million. He next starred in films like ‘Aruba’ (2006), ‘Citizen Duane’ (2006), ‘American Pie Presents: The Naked Mile’ (2007), ‘The Poet’ (2007), ‘Finn's Girl’ (2007), ‘The Stone Angel’ (2007), ‘Adoration’ (2008), and ‘Survival of the Dead’ (2009).
In 2009, he starred as ‘Brent’ in the horror film ‘Saw VI,’ directed by Kevin Greutert. The film saw mixed reviews upon release and did decent business at the box office. The following year, he appeared in the American comedy film ‘Diary of a Wimpy Kid,’ where he played the role of ‘Rodrick Heffley.’ The film received mixed reviews from critics and was a major box office success, grossing over $75.7 million against a budget of $15 million. He reprised his role as ‘Rodrick Heffley’ in ‘Diary of a Wimpy Kid: Rodrick Rules’ (2011) and ‘Diary of a Wimpy Kid: Dog Days’ (2012). He starred as ‘Casper Galloway’ in the 2012 Canadian adventure-horror comedy ‘Dead Before Dawn,' directed by April Mullen. The film failed to impress the critics. In 2013, he appeared in the Canadian comedy film ‘The Art of the Steal,’ directed by Jonathan Sobol. The film opened to mixed reception.
In 2014, he joined the main cast of the American post-apocalyptic science fiction drama television series ‘The 100.’ He played the role of ‘Jasper Jordan’ and remained a part of the show until 2017. In 2019, he starred as ‘Tommy’ in the six-episode American limited television series ‘I Am the Night,’ created by Sam Sheridan. The series received mixed response from critics. Bostick was last seen in the 2020 American coming-of-age romantic drama film ‘Words on Bathroom Walls,’ directed by Thor Freudenthal. The film earned considerable praise from critics. He is all set to appear in the upcoming thriller film ‘Salvation’ where he will play the role of ‘Luke.’