Boyd Holbrook made his debut in the 2008 American biographical film ‘Milk’ directed by Gus Van Sant. The film opened to universal acclaim and received 8 ‘Academy Award’ nominations. In 2011, he appeared in the American drama film ‘Higher Ground’ directed by Vera Farmiga. The film opened to a positive reception and earned an 81% approval rating on Rotten Tomatoes. The following year, he starred as Luke Ford in the drama film ‘The Magic of Belle Isle’ directed by Rob Reiner. The film saw mostly negative reviews upon release. In 2013, he portrayed Kyle O'Shea in the American romantic science fiction thriller film ‘The Host’ directed by Andrew Niccol. The film was panned by critics and grossed over $40 million on a budget of $63.3 million. That same year, he also appeared in the American crime drama film ‘Out of the Furnace’ which received a mixed response from critics. He continued to star in films like ‘The Skeleton Twins’ (2014), ‘Little Accidents’ (2014), ‘Gone Girl’ (2014), ‘Run All Night’ (2015), ‘The Free World’ (2016), ‘Jane Got a Gun’ (2016), ‘Morgan’ (2016), and ‘Cardboard Boxer’ (2016).
In 2017, he portrayed Donald Pierce in the American superhero film ‘Logan’ directed by James Mangold. The film was warmly received by critics and was a major commercial success, grossing over $619.2 million on a budget of $97–127 million. The following year, he starred as Pinkins’ in the American drama fiction film, ‘O.G.’ directed by Madeleine Sackler. The film received a positive response from critics. The same year, he also played the role of ‘Quinn McKenna’ in the American science fiction action film ‘The Predator’ directed by Shane Black. The film received a lukewarm response from critics. He was next seen in films like ‘In the Shadow of the Moon’ (2019), ‘We Can Be Heroes’ (2020), and ‘The Cursed’ (2021). Holbrook was last seen in the 2021 action thriller film ‘Beckett’ directed by Ferdinando Cito Filomarino. The film received a mixed response from critics. He will be next seen in the upcoming American horror-thriller film, ‘Vengeance.’