Alexis Arquette underwent male to female transition by sex reassignment surgery in 2006. Her experiences were documented in the film āAlexis Arquette: Sheās My Brother,ā which was screened at the 'Tribeca Film Festival,' in 2007.Ā
She has appeared in both male as well as female roles in films and television. In her early years, she mostly played the role of a female impersonator, by the name of 'Eva Destruction.'Ā
At the age of 19, she played the role of a trans sex worker in the screen adaption of āLast Exit to Brooklynā. Her notable performances include films like āOf Mice and Menā (1992), āPulp Fictionā (1994), and āWigstock: The Movieā (1995).Ā
Her films āChildren of the Corn V: Fields of Terrorā (1998) and āThe Prince of Airā (2000) failed at the box office.Ā
Arquette has appeared in a number of television series and she has received positive reviews for her performances in āBeggars and Choosersā (1999 - 2001) and āRoseanneā (1994 ā 1995).Ā
She failed to make an impact in her role as 'Cleo' in āThe Stripā (1999).Ā