Alexis Arquette underwent male to female transition by sex reassignment surgery in 2006. Her experiences were documented in the film ‘Alexis Arquette: She’s My Brother,’ which was screened at the 'Tribeca Film Festival,' in 2007.
She has appeared in both male as well as female roles in films and television. In her early years, she mostly played the role of a female impersonator, by the name of 'Eva Destruction.'
At the age of 19, she played the role of a trans sex worker in the screen adaption of ‘Last Exit to Brooklyn’. Her notable performances include films like ‘Of Mice and Men’ (1992), ‘Pulp Fiction’ (1994), and ‘Wigstock: The Movie’ (1995).
Her films ‘Children of the Corn V: Fields of Terror’ (1998) and ‘The Prince of Air’ (2000) failed at the box office.
Arquette has appeared in a number of television series and she has received positive reviews for her performances in ‘Beggars and Choosers’ (1999 - 2001) and ‘Roseanne’ (1994 – 1995).
She failed to make an impact in her role as 'Cleo' in ‘The Strip’ (1999).