Mackenzie Davis made her debut in the 2012 American drama film ‘Smashed’ where she portrayed Millie. The film received a positive response from critics. In 2013, she starred as ‘Lauren Reynolds’ in the American romantic drama film ‘Breathe In’ directed by Drake Doremus. The film received mixed reviews from critics and scored a 56% approval rating on Rotten Tomatoes. That same year, she also appeared in the romantic comedy film ‘The F Word’ which garnered positive reviews from critics. In 2014, she starred as ‘Chelsea’ in the American romantic comedy-drama film ‘That Awkward Moment’ directed by Tom Gormican. Even though the film was panned by critics, it managed to gross over $40.5 million on a budget of $8 million. That same year, she joined the cast of the main cast of the American period drama television series, ‘Halt and Catch Fire.’ She played the role of ‘Cameron Howe’ and remained a part of the series until it went off-air in 2017.
The year 2015 saw the release of the science fiction film ‘The Martian’ where Davis played the role of ‘Mindy Park.’ The film was lauded by critics and bagged 7 ‘Academy Award’ nominations. ‘The Martian’ was also a major financial success and grossed over $630.2 million on a $108 million budget. She next appeared in films like ‘Always Shine’ (2016), ‘Izzy Gets the F*ck Across Town’ (2017), ‘Blade Runner 2049’ (2017), ‘Boomerang’ (2018), and ‘Tully’ (2018). In 2019, she portrayed Grace Harper in the American science fiction action film and the sixth installment in the Terminator franchise, ‘Terminator: Dark Fate.’ While the film received a positive response from critics, it failed to perform at the box office and ended up becoming a commercial disaster. The following year, she appeared in the American supernatural horror film ‘The Turning’ directed by Floria Sigismondi. The film was marred by negative reviews from critics and was given a 13% approval rating on Rotten Tomatoes. The same year, she was also seen in the American holiday romantic comedy-drama film ‘Happiest Season.’ The film was well-received by the critics. In 2021, she became a part of the American post-apocalyptic dystopian fiction miniseries, ‘Station Eleven’ where she played the role of Kirsten Raymonde. The series aired 10 episodes before going off-air in January 2022.