Jacqueline Fernandez made her debut in the 2009 Indian Hindi-language fantasy action comedy film ‘Aladin’ directed by Sujoy Ghosh. The film received a lukewarm response from critics and underperformed at the box office. The following year, she starred as ‘Tara’ in the Milap Milan Zaveri-directed Bollywood science fiction romance film ‘Jaane Kahan Se Aayi Hai.’ The film received a mixed response from critics. That same year, she also appeared in the song "Aapka Kya Hoga (Dhanno)" in the Indian Hindi-language comedy film ‘Housefull’ directed by Sajid Khan. In 2011, she played the role of ‘Priya’ in the Indian Hindi-language psychological thriller film ‘Murder 2’ directed by Mohit Suri. The film received mixed to positive reviews from critics and did decent business at the box office, grossing over ₹67.84 crores on a budget of ₹13 crores. She next appeared in films like ‘Housefull 2’ (2012), ‘Race 2’ (2013), and ‘Ramaiya Vastavaiya’ (2013) special appearance in the song "Jadoo Ki Jhappi." In 2014, she portrayed Shaina Mehra in the Sajid Nadiadwala-directed Indian Hindi-language action comedy film, ‘Kick.’ The film opened to a sort of positive critical reception and turned out to be a massive box office success, grossing over ₹402 crores on a budget of ₹140 crores.
She next starred in films like ‘Roy’ (2015), ‘Brothers’ (2015), ‘Definition of Fear’ (2015), ‘Housefull 3’ (2016), ‘Dishoom’ (2016), ‘A Flying Jatt’ (2016), ‘According to Mathew’ (2017), ‘A Gentleman’ (2017), ‘Judwaa 2’ (2017), ‘Race 3’ (2018), ‘Drive’ (2019), ‘Mrs. Serial Killer’ (2020), ‘Bhoot Police’ (2021), and ‘Bachchhan Paandey’ (2022). She was last seen in the 2022 Indian Hindi-language science fiction action film ‘Attack: Part 1’ directed by Lakshya Raj Anand. The film received mixed reviews from critics but failed to perform at the box office. She will be next seen in the upcoming Indian Hindi-language comedy film ‘Cirkus’ where she will play the role of ‘Chahat Joshi.’