Michael Blackson made his big-screen debut in the 2000 stoner comedy film ‘Next Friday’ directed by Steve Carr. While the film was panned by critics, it managed to do decent business at the box office. In 2005, he released his best-selling comedy CD titled ‘Modasucka: Welcome to America.’ He appeared in the television series ’30 Rock’ that same year. After a four-year hiatus, Blackson returned to the big screens in 2006 with the film ‘The Last Stand.’
He then starred in films like ‘Banana Leaves’ (2007), ‘The Mail Man’ (2009), ‘My American Nurse 2’ (2010), ‘Threading Needles’ (2011), and ‘In Sickness and in Health’ (2012). In 2013, Blackson starred as ‘Mr. Roland’ in the comedy film ‘One Night in Vegas’ directed by John Uche. The film was met with critical acclaim upon its release and earned several ‘NAFC Award’ nominations.
The year 2016 saw the release of the Deon Taylor-directed comedy horror film ‘Meet the Blacks’ where Blackson was seen playing the role of ‘Mr. Wooky.’ The film received negative reviews from the audience and critics but was a box office success. In 2018, he starred in the romantic comedy film ‘Nobody's Fool.’ The film was not well-received by critics and could achieve moderate success at the box office.
In 2021, Michael Blackson appeared in ‘Coming 2 America,’ the sequel to the 1988 comedy film Coming to America. The film opened to mixed reviews from critics. That same year, he starred in the Deon Taylor-directed comedy horror film ‘The House Next Door: Meet the Blacks 2.’