Danai Gurira made her screen debut in the Episode: "Inert Dwarf" of the American police procedural drama television series ‘Law & Order: Criminal Intent’ in 2004. In 2007, she made her silver screen debut in the American drama film ‘The Visitor’ directed by Tom McCarthy. The film garnered praise from critics and grossed over $18.1 million on a budget of $4 million. In 2010, she played the role of ‘Jeanne-Baptiste’ in the American slasher film ‘My Soul to Take’ directed by Wes Craven. The film was a critical and commercial failure. The following year, she played the role of ‘Sisi’ in the independent drama film ‘Restless City’ directed by Andrew Dosunmu. In 2012, she joined the main cast of the American post-apocalyptic horror television series ‘The Walking Dead’ developed by Frank Darabont. She played the role of ‘Michonne’ and remained a part of the show until 2020. She was also seen in films like ‘Mother of George’ (2013), ‘Tinker Bell and the Legend of the NeverBeast’ (2015), and ‘All Eyez on Me’ (2017). In 2018, she portrayed ‘Okoye’ in the American superhero film ‘Black Panther’ directed by Ryan Coogler. The film saw critical acclaim upon release and was a massive box office success, grossing over $1.348 billion on a budget of $200 million. She reprised her role as ‘Okoye’ in ‘Avengers: Infinity War’ (2018) and ‘Avengers: Endgame’ (2019) which were also massive box office hits.
She last appeared in the American animated anthology series ‘What If...?’ in 2021. She voiced ‘Okoye’ and starred in 3 episodes. Gurira will be next seen in the upcoming American superhero film ‘Black Panther: Wakanda Forever.’