Chandler Riggs made his film debut in the 2006 comedy-horror sci-fi film ‘Jesus H. Zombie’ where he played the role of ‘Egon / Zombie.’ In 2009, he starred as ‘Tom’ in the drama film ‘Get Low’ directed by Aaron Schneider. The film saw its premiere at the Toronto International Film Festival and garnered praise from critics upon release. The following year, he appeared in the television film ‘The Wronged Man.’ That same year, he joined the main cast of the American post-apocalyptic horror television series ‘The Walking Dead’ based on Robert Kirkman, Tony Moore, and Charlie Adlard’s comic book series of the same name. He portrayed ‘Carl Grimes’ and remained a part of the series until it went off-air in 2018. Riggs also became a recipient of a number of awards and accolades, including a 'Satellite Award' (shared with cast members), 3 individual 'Saturn Awards,' and a 'Young Artist Award.'
In 2014, Riggs was seen playing the role of ‘George Bruckner’ in the American supernatural horror film ‘Mercy’ directed by Peter Cornwell. He next appeared in the American horror-thriller film ‘Keep Watching’ directed by Sean Carter. That same year, he also voiced his 'The Walking Dead' character ‘Carl Grimes’ in the Episode: "The Robot Chicken Walking Dead Special: Look Who’s Walking" of the American adult animated stop motion sketch comedy television series ‘Robot Chicken.’ He played the role of ‘Cooper’ in the American crime drama film ‘Inherit the Viper’ directed by Anthony Jerjen. The film received a mixed response from critics. The same year, he became a part of the American family drama television series ‘A Million Little Things’ created by DJ Nash. The series was renewed for a fourth season in September 2021.